SCHEMBL28548628

SCHEMBL28548628

COc1ccc(C(=O)ON2C(=O)c3ccccc3C2=O)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.60
NPC1 O15118 2/20 0.58
POLB P06746 2/20 0.53
HSP90AA1 P07900 1/20 0.53
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
RECQL P46063 1/20 0.51
HDAC3 O15379 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
HDAC9 Q9UKV0 1/20 0.50
HDAC5 Q9UQL6 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
TNF P01375 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16142447 0.88 ALDH1A1 (0.50) GAANPC1POLBCA1CA2
SCHEMBL8778072 0.85 S100A4 (0.50) GAANPC1POLBHSP90AA1SMN1; SMN2
SCHEMBL491136 0.83 ALDH1A1 (0.57) GAAPOLBCA1CA2SMN1; SMN2
SCHEMBL29082812 0.82 ALDH1A1 (0.56) GAAPOLBCA1CA2SMN1; SMN2
SCHEMBL13479793 0.81 ALDH1A1 (0.55) GAAPOLBSMN1; SMN2CYP1A2CYP2C9
SCHEMBL11073957 0.81 KMT2A (0.51) POLBRECQLSMN1; SMN2CES2CES1
SCHEMBL11756900 0.80 ALDH1A1 (0.49) GAAPOLBCA1CA2SMN1; SMN2
SCHEMBL13799576 0.79 KDM4E (0.49) GAANPC1HSP90AA1SMN1; SMN2MEN1
SCHEMBL28548636 0.78 NPC1 (0.59) GAANPC1POLBRECQLHDAC1
SCHEMBL7280246 0.78 TP53 (0.55) NPC1RECQLSMN1; SMN2CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112746289-B Synthesis method of alkyl borate compound 合肥工业大学 2021-11-09 CN disclosed
CN-112746289-A Synthesis method of alkyl borate compound 合肥工业大学 2021-05-04 CN disclosed