Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CCR1 | P32246 | 3/20 | 0.47 |
| ▸ | CCR5 | P51681 | 3/20 | 0.47 |
| ▸ | CCR8 | P51685 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074407 | 1.00 | LMNA (0.59) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL9872273 | 0.92 | LMNA (0.65) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL28483310 | 0.80 | CYP3A4 (0.53) | LMNAKDM4EMAPTCYP3A4TSHR | |
| SCHEMBL1246514 | 0.78 | CCR1 (0.75) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL27885494 | 0.77 | LMNA (0.96) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL5620303 | 0.77 | MAPT (0.67) | LMNAKDM4EMAPTCYP3A4TSHR | |
| SCHEMBL960574 | 0.75 | CYP3A4 (0.57) | LMNAKDM4EMAPTCYP3A4TSHR | |
| SCHEMBL8313 | 0.75 | LMNA (1.00) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL6513577 | 0.75 | LMNA (1.00) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL346255 | 0.75 | LMNA (0.65) | LMNACCR1CCR5CCR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112442032-B | Preparation method of medicine intermediate benzopyrimidinoquinolinone derivative | 南京苏亦欣医药科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-112442032-A | Preparation method of medicine intermediate benzopyrimidinoquinolinone derivative | 南京苏亦欣医药科技有限公司 | 2021-03-05 | — | — | CN | disclosed |