SCHEMBL28549486

SCHEMBL28549486

O=P(O)(O)c1c(O)ccc2ccc(Br)cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.44
GALR3 O60755 1/20 0.44
ERN1 O75460 2/20 0.44
ALOX15 P16050 2/20 0.41
HPGD P15428 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CASP1 P29466 1/20 0.40
CYP2C19 P33261 1/20 0.40
MAPT P10636 3/20 0.38
HTT P42858 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
PIM1 P11309 1/20 0.38
ALDH1A1 P00352 2/20 0.37
PLG P00747 1/20 0.37
PLAU P00749 1/20 0.37
PLAT P00750 1/20 0.37
POLB P06746 1/20 0.36
ESR2 Q92731 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28560430 0.88 ERN1 (0.54) CES2GALR3ERN1ALOX15HPGD
SCHEMBL3280396 0.76 PTPN22 (0.52) ERN1HPGDCYP1A2CYP2C9CYP2C19
SCHEMBL3282140 0.75 PTPN1 (0.41) CES2ERN1HPGDCYP1A2CYP2C19
SCHEMBL28558770 0.75 MTNR1A (0.46) ERN1HPGDCYP1A2MAPTNPC1
SCHEMBL29218979 0.72 PTPN22 (0.52) CES2GALR3ERN1ALOX15HPGD
SCHEMBL5362507 0.72 ALOX15 (0.50) CES2GALR3ERN1ALOX15HPGD
SCHEMBL5752732 0.72 POLB (0.59) CES2GALR3ERN1ALOX15HPGD
SCHEMBL29833499 0.72 POLB (0.59) CES2GALR3ERN1ALOX15HPGD
SCHEMBL6560733 0.72 GRIN2D (0.44) ALOX15HPGDCYP1A2CASP1MAPT
SCHEMBL15779259 0.71 ALOX15 (0.54) CES2GALR3ERN1ALOX15HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112574251-B Preparation method of visible light-promoted 1-phosphonyl-2-naphthol derivative 河南工业大学 2022-09-30 CN disclosed
CN-112574251-A Preparation method of visible light-promoted 1-phosphonyl-2-naphthol derivative 河南工业大学 2021-03-30 CN disclosed