Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTMT1 | Q9BV86 | 18/20 | 0.49 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862222 | 1.00 | NTMT1 (0.49) | NTMT1UGCGCYP1A2CYP2D6HAO1 | |
| SCHEMBL2853360 | 0.94 | NTMT1 (0.49) | NTMT1UGCGCYP1A2CYP2D6 | |
| SCHEMBL2853356 | 0.94 | NTMT1 (0.49) | NTMT1UGCGCYP1A2CYP2D6 | |
| SCHEMBL2856674 | 0.92 | NTMT1 (0.47) | NTMT1UGCGHAO1 | |
| SCHEMBL2854171 | 0.92 | NTMT1 (0.47) | NTMT1UGCGHAO1 | |
| SCHEMBL2851660 | 0.92 | NTMT1 (0.47) | NTMT1UGCGHAO1 | |
| Formic Acid SCHEMBL2855542 | 0.89 | NTMT1 (0.45) | NTMT1UGCGHAO1 | |
| Formic Acid SCHEMBL2855811 | 0.89 | NTMT1 (0.45) | NTMT1UGCGHAO1 | |
| SCHEMBL2860642 | 0.87 | P2RX3 (0.41) | NTMT1CYP1A2CYP2D6 | |
| SCHEMBL2857814 | 0.87 | P2RX3 (0.41) | NTMT1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828179-B1 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS-RELATED DISEASES | MEMORY PHARM CORP (US) | 2010-01-20 | — | — | EP | claimed |
| US-7625924-B2 | Nicotinic alpha-7 receptor ligands and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-12-01 | — | — | US | claimed |
| WO-2007136640-A2 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLE-1,3-DIONE | CELGENE CORPORATION (US) | 2007-11-29 | — | — | WO | claimed |
| US-20060167039-A1 | Nicotinic alpha-7 receptor ligands and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION | 2006-07-27 | — | — | US | claimed |
| EP-3601255-A1 | PROLINE AMIDE COMPOUNDS AND THEIR AZETIDINE ANALOGUES CARRYING A SPECIFICALLY SUBSTITUTED BENZYL RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018175449-A1 | PROLINE AMIDE COMPOUNDS AND THEIR AZETIDINE ANALOGUES CARRYING A SPECIFICALLY SUBSTITUTED BENZYL RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2018-09-27 | — | — | WO | disclosed |
| US-20100016351-A1 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | NGUYEN TRUC MINH | 2010-01-21 | — | — | US | disclosed |
| EP-1828179-B1 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS-RELATED DISEASES | MEMORY PHARM CORP (US) | 2010-01-20 | — | — | EP | disclosed |
| US-7625924-B2 | Nicotinic alpha-7 receptor ligands and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1866346-A1 | AZO COMPOUNDS FOR POLYPROPYLENE DEGRADATION | Ciba Specialty Chemicals Holding Inc. (CH) | 2007-12-19 | — | — | EP | disclosed |
| EP-1861485-A1 | ANTIWEAR LUBRICANT COMPOSITIONS FOR USE IN COMBUSTION ENGINES | Ciba Specialty Chemicals Holding Inc. (CH) | 2007-12-05 | — | — | EP | disclosed |
| EP-1771068-A1 | SUBSTITUTED 1H-PYRROLE-2,5-DIONES | Bayer CropScience Aktiengesellschaft (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006100188-A1 | ANTIWEAR LUBRICANT COMPOSITIONS FOR USE IN COMBUSTION ENGINES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-09-28 | — | — | WO | disclosed |
| US-20060167039-A1 | Nicotinic alpha-7 receptor ligands and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION | 2006-07-27 | — | — | US | disclosed |
| WO-2006007998-A1 | SUBSTITUTED 1H-PYRROLE-2,5-DIONES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-01-26 | — | — | WO | disclosed |
| EP-1320521-A1 | 2-THIOCARBAMOYLOXY AND 2-CARBAMOYLOXY DERIVATIVES OF CYCLOPENTYL-HEPTAN(EN)OIC ACID AS THERAPEUTIC AGENTS | Allergan, Inc. (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002026704-A1 | 2-THIOCARBAMOYLOXY AND 2-CARBAMOYLOXY DERIVATIVES OF CYCLOPENTYL-HEPTAN(ENE)OIC ACID AS THERAPEUTIC AGENTS | ALLERGAN INC. (US) | 2002-04-04 | — | — | WO | disclosed |
| EP-0851899-A1 | BENZOTHIOPHENE-2-CARBOXAMIDE-S,S-DIOXIDES FOR USE IN ANTI-FOULING APPLICATIONS | BAYER AG (DE) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997011131-A1 | BENZOTHIOPHENE-2-CARBOXAMIDE-S,S-DIOXIDES FOR USE IN ANTI-FOULING APPLICATIONS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-03-27 | — | — | WO | disclosed |
| EP-0225472-A1 | Substituted pyrazolin-5-ones | BAYER AG (DE) | 1987-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167039-A1 | Nicotinic alpha-7 receptor ligands and preparation and uses thereof | CHRNA7, CHRNA5, CHRNA6 | NTMT1 927/4885UGCG 2056/4885CYP1A2 2614/4885 |
| US-20100016351-A1 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA6 | NTMT1 927/4885UGCG 2056/4885CYP1A2 2614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.