Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | FER | P16591 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MARK3 | P27448 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | STK3 | Q13188 | 2/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28560103 | 0.84 | LRRK2 (0.48) | MAPK1MAPTDYRK1AMAP4K4MINK1 | |
| SCHEMBL28559332 | 0.83 | DYRK1A (0.44) | MAPK1DYRK1AMAP4K4MINK1DYRK1B | |
| SCHEMBL28553364 | 0.81 | DYRK1B (0.39) | DYRK1AMAP4K4MINK1DYRK1BPRKD3 | |
| SCHEMBL16025493 | 0.79 | FLT3 (0.62) | IDO1MAPK1MAPTDYRK1ANFATC1 | |
| SCHEMBL5061384 | 0.78 | DYRK1A (0.57) | IDO1DYRK1AMAP4K4MINK1DYRK1B | |
| SCHEMBL28603327 | 0.77 | DYRK1A (0.63) | IDO1MAPK1DYRK1ANFATC1MAP4K4 | |
| SCHEMBL29930372 | 0.77 | DYRK1B (0.60) | DYRK1AMAP4K4MINK1DYRK1BPRKD3 | |
| SCHEMBL28558865 | 0.76 | DYRK1A (0.34) | DYRK1AMAP4K4MINK1DYRK1BPRKD3 | |
| SCHEMBL29930770 | 0.76 | DYRK1B (0.58) | IDO1MAPK1DYRK1AMAP4K4MINK1 | |
| SCHEMBL29930377 | 0.75 | DYRK1B (0.61) | DYRK1AMAP4K4MINK1DYRK1BPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112724134-B | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2022-04-01 | — | — | CN | disclosed |
| CN-112724134-A | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-04-30 | — | — | CN | disclosed |