Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.60 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28559332 | 0.80 | DYRK1A (0.44) | DYRK1BCDK8DYRK1ACDK5MAP4K4 | |
| SCHEMBL5061384 | 0.78 | DYRK1A (0.57) | DYRK1BCDK8DYRK1ACDK5MAP4K4 | |
| SCHEMBL28553364 | 0.78 | DYRK1B (0.39) | DYRK1BCDK8DYRK1ACDK5MAP4K4 | |
| SCHEMBL28556801 | 0.77 | IDO1 (0.44) | DYRK1BDYRK1ACDK5MAP4K4FGFR1 | |
| SCHEMBL29930770 | 0.76 | DYRK1B (0.58) | DYRK1BMAPKAPK2CDK8DYRK1ACDK5 | |
| SCHEMBL28560103 | 0.75 | LRRK2 (0.48) | DYRK1BCDK8DYRK1ACDK5MAP4K4 | |
| SCHEMBL28553148 | 0.75 | DYRK1B (0.56) | DYRK1BCDK8DYRK1ACDK5MAP4K4 | |
| SCHEMBL7943191 | 0.73 | PIM1 (0.42) | DYRK1BCDK8DYRK1ACDK5MAP4K4 | |
| SCHEMBL38652158 | 0.72 | AURKA (0.48) | DYRK1BDYRK1ACDK5MAP4K4FGFR1 | |
| SCHEMBL28562998 | 0.72 | DYRK1B (0.61) | DYRK1BDYRK1ASYKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |