SCHEMBL2855751

SCHEMBL2855751

CCn1cc(OC(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.78
CYP2C9 P11712 2/20 0.78
ATP6V1B2 P21281 1/20 0.78
TBXA2R P21731 1/20 0.78
EDNRA P25101 1/20 0.78
TARBP2 Q15633 1/20 0.78
HSD17B10 Q99714 6/20 0.50
ALDH1A1 P00352 6/20 0.50
KDM4E B2RXH2 5/20 0.50
HPGD P15428 5/20 0.50
BRD4 O60885 1/20 0.50
TSHR P16473 1/20 0.50
HTT P42858 1/20 0.50
CYP2J2 P51589 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
PMP22 Q01453 1/20 0.40
CASP1 P29466 1/20 0.39
DRD3 P35462 1/20 0.38
CYP1A2 P05177 1/20 0.37
TOP2A P11388 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10703698 0.90 LMNA (0.63) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Asparagine SCHEMBL11011678 0.90 LMNA (0.64) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL10913668 0.89 LMNA (0.71) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Glutamic Acid SCHEMBL11015624 0.89 LMNA (0.63) LMNACYP2C9ATP6V1B2TBXA2REDNRA
SCHEMBL11324091 0.88 LMNA (0.61) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Enoxacin SCHEMBL33963 0.88 LMNA (1.00) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Enoxacin SCHEMBL29384458 0.88 LMNA (1.00) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Enoxacin SCHEMBL2635855 0.88 LMNA (1.00) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Glucuronic Acid SCHEMBL11007046 0.88 LMNA (0.61) LMNACYP2C9ATP6V1B2TBXA2REDNRA
Enoxacin SCHEMBL11289413 0.87 LMNA (0.98) LMNACYP2C9ATP6V1B2TBXA2REDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1408034-B1 Use of Quinolone and Quinolizinone derivatives as chemotherapeutic agents SCHULZ & SCHLIMBACH GBR (DE) 2007-08-08 EP claimed
EP-1143950-B1 TOPICAL APPLICATION PRODUCTS AGAINST ONYCHOMYCOSES BIOEQUAL AG (CH) 2005-03-09 EP claimed
EP-1408034-A1 Use of Quinoline derivatives as antibacterial agents Schulz & Schlimbach GbR (DE) 2004-04-14 EP claimed
EP-1244434-A2 USE OF CHEMOTHERAPEUTIC AGENTS Schulz, Hans-Herrmann (DE) 2002-10-02 EP claimed
WO-2001045679-A2 USE OF CHEMOTHERAPEUTIC AGENTS FOR TOPICAL TREATMENT SCHULZ HANS HERRMANN (DE) 2001-06-28 WO claimed
EP-0240391-B1 SILVER SALT DERIVED FROM NAPHTHYRIDINE, USEFUL AS A BACTERICIDE, PROCESS FOR ITS PREPARATION AND COMPOSITIONS CONTAINING IT EDMOND PHARMA S.R.L. (IT) 1991-07-10 EP claimed
EP-0210513-A1 Preparations for the treatment of mycoplasmoses and bacterial infections in poultry BAYER AG (DE) 1987-02-04 EP claimed
EP-0058614-B1 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-1,8 NAPHTYRIDINE-3-CARBOXYLIC ACID. SESQUIHYDRATE, PROCESSES FOR THE PREPARATION THEREOF AND USE THEREOF AS ANTIBACTERIAL AGENTS Société anonyme dite: LABORATOIRE ROGER BELLON (FR) 1985-09-18 EP claimed
EP-0009425-B1 NOVEL NAPHTYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Société anonyme dite: LABORATOIRE ROGER BELLON (FR) 1982-01-27 EP claimed
EP-1682144-B1 PHARMACEUTICAL FORMULATIONS CONTAINING FLAVOURING SUBSTANCES WITH IMPROVED PHARMACEUTICAL PROPERTIES BAYER ANIMAL HEALTH GMBH (DE) 2010-01-13 EP disclosed
EP-2080515-A1 Pharmaceutical formulations containing flavouring substances with improved pharmaceutical properties Bayer Animal Health GmbH (DE) 2009-07-22 EP disclosed
EP-1680076-B1 PHARMACEUTICAL AND COSMETIC FORMULATIONS FOR TREATING FINGERNAILS BIOEQUAL AG (CH) 2008-07-02 EP disclosed
EP-1408034-B1 Use of Quinolone and Quinolizinone derivatives as chemotherapeutic agents SCHULZ & SCHLIMBACH GBR (DE) 2007-08-08 EP disclosed
EP-1682144-A1 PHARMACEUTICAL FORMULATIONS CONTAINING FLAVOURING SUBSTANCES WITH IMPROVED PHARMACEUTICAL PROPERTIES Bayer HealthCare AG (DE) 2006-07-26 EP disclosed
EP-0138018-B1 SOLUTIONS OF LACTIC ACID SALTS OF PIPERAZINYLQUINOLONE AND PIPERAZINYL AZAQUINOLONECARBOXYLIC ACIDS BAYER AG (DE) 1988-11-02 EP disclosed
EP-0210513-A1 Preparations for the treatment of mycoplasmoses and bacterial infections in poultry BAYER AG (DE) 1987-02-04 EP disclosed
EP-0205029-A2 Quinolinecarboxylic acids with an antibacterial activity BAYER AG (DE) 1986-12-17 EP disclosed
EP-0187315-A2 Basic quinolonecarboxylic-acid preparations BAYER AG (DE) 1986-07-16 EP disclosed
EP-0187376-A2 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids BAYER AG (DE) 1986-07-16 EP disclosed
EP-0138018-A2 Solutions of lactic acid salts of piperazinylquinolone and piperazinyl azaquinolonecarboxylic acids BAYER AG (DE) 1985-04-24 EP disclosed