Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | BRD4 | O60885 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 4/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29724104 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL13576340 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL28559532 | 0.85 | HSD17B10 (0.58) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL11997101 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL10048249 | 0.83 | KDM4E (0.72) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL28564270 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| Norfloxacin SCHEMBL3473 | 0.80 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL10028896 | 0.80 | KDM4E (0.84) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| Norfloxacin SCHEMBL2221304 | 0.80 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| Norfloxacin SCHEMBL27395494 | 0.80 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112824388-B | Acrylic ketone derivative of norfloxacin and preparation method and application thereof | 河南大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-112824388-A | Acrylic ketone derivative of norfloxacin, and preparation method and application thereof | 河南大学 | 2021-05-21 | — | — | CN | disclosed |