Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.33 |
| ▸ | PIM1 | P11309 | 5/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549707 | 0.74 | PARP1 (0.44) | LIMK1PARP1KDM4EL3MBTL1 | |
| SCHEMBL17818822 | 0.72 | PTGDR2 (0.39) | NTRK1PIM1ACVR1CDK8 | |
| SCHEMBL10560583 | 0.71 | ADORA3 (0.35) | NOS3NOS2NTRK1L3MBTL1 | |
| SCHEMBL4096931 | 0.70 | SLC9A1 (0.36) | TDP1PARP1 | |
| SCHEMBL20740807 | 0.68 | DAO (0.34) | KDM4E | |
| SCHEMBL28442923 | 0.67 | LIMK1 (0.42) | LIMK1SIRT3TDP1NTRK1PIM1 | |
| SCHEMBL7851904 | 0.66 | NTRK1 (0.35) | NTRK1PIM1ACVR1CCNCCDK8 | |
| SCHEMBL28360828 | 0.65 | LMNA (0.32) | — | |
| SCHEMBL29065343 | 0.65 | KDM4E (0.40) | LIMK1NOS3NOS2PARP1KDM4E | |
| SCHEMBL16516801 | 0.65 | LIMK1 (0.75) | LIMK1CDK8KDM4EABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112088157-A | Aryl-bipyridine amine derivatives as phosphoinositide kinase inhibitors | 拉文纳制药公司 | 2020-12-15 | — | — | CN | disclosed |