Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20265293 | 0.86 | POLB (0.56) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2855124 | 0.85 | KDM4E (0.47) | MAPTSMN1; SMN2POLBKMT2AKDM4E | |
| SCHEMBL2848347 | 0.84 | GAA (0.51) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2854304 | 0.82 | NPC1 (0.49) | MAPTSMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL11641804 | 0.82 | TSHR (0.43) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL11387868 | 0.82 | TSHR (0.43) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2856308 | 0.81 | SPR (0.51) | KDM4EALDH1A1RAB9AMALT1NPC1 | |
| SCHEMBL24802622 | 0.80 | MAPT (0.69) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2299344 | 0.80 | MAPT (0.69) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL30785613 | 0.79 | MAPT (0.68) | MAPTSMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |