Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.31 |
| ▸ | PDE4A | P27815 | 3/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886669 | 1.00 | EGFR (0.37) | EGFRERBB2MAPK8MAPK9IKBKE | |
| SCHEMBL21886628 | 0.89 | ERBB2 (0.39) | EGFRERBB2MAPK8MAPK9IKBKE | |
| SCHEMBL28555129 | 0.89 | ERBB2 (0.39) | EGFRERBB2MAPK8MAPK9IKBKE | |
| SCHEMBL28569853 | 0.87 | PDE4D (0.36) | EGFRERBB2MAPK8MAPK9CHEK1 | |
| SCHEMBL28569856 | 0.87 | PDE4D (0.36) | EGFRERBB2MAPK8MAPK9CHEK1 | |
| SCHEMBL25987141 | 0.85 | ERBB2 (0.37) | EGFRERBB2TBK1VEGFACHEK1 | |
| SCHEMBL21886635 | 0.84 | EGFR (0.35) | EGFRERBB2IKBKETBK1CHEK1 | |
| SCHEMBL30988768 | 0.82 | ERBB2 (0.34) | ERBB2TBK1CHEK1 | |
| SCHEMBL28559957 | 0.80 | CHEK1 (0.38) | EGFRERBB2MAPK8MAPK9CHEK1 | |
| SCHEMBL21886730 | 0.80 | CHEK1 (0.38) | EGFRERBB2MAPK8MAPK9CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255772-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-112654612-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2021-04-13 | — | — | CN | disclosed |