Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.31 |
| ▸ | PDE4A | P27815 | 3/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886628 | 1.00 | ERBB2 (0.39) | ERBB2EGFRIKBKETBK1ALK | |
| SCHEMBL28564240 | 0.89 | EGFR (0.37) | ERBB2EGFRIKBKETBK1ALK | |
| SCHEMBL21886669 | 0.89 | EGFR (0.37) | ERBB2EGFRIKBKETBK1ALK | |
| SCHEMBL25987137 | 0.85 | ERBB2 (0.38) | ERBB2EGFRTBK1CHEK1 | |
| SCHEMBL28569856 | 0.85 | PDE4D (0.36) | ERBB2EGFRCHEK1PDE4BPDE4D | |
| SCHEMBL28569853 | 0.85 | PDE4D (0.36) | ERBB2EGFRCHEK1PDE4BPDE4D | |
| SCHEMBL21886635 | 0.84 | EGFR (0.35) | ERBB2EGFRIKBKETBK1CHEK1 | |
| SCHEMBL21886828 | 0.83 | GPR119 (0.37) | TBK1ALKPDE4BPDE4DPDE4A | |
| SCHEMBL30988767 | 0.83 | GPR119 (0.37) | TBK1ALKPDE4BPDE4DPDE4A | |
| SCHEMBL28560474 | 0.83 | GPR119 (0.37) | TBK1ALKPDE4BPDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255772-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-112654612-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2021-04-13 | — | — | CN | disclosed |