Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.36 |
| ▸ | PDE4A | P27815 | 6/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | FASN | P49327 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28569856 | 1.00 | PDE4D (0.36) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL21886669 | 0.87 | EGFR (0.37) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL28564240 | 0.87 | EGFR (0.37) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL28555129 | 0.85 | ERBB2 (0.39) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL21886628 | 0.85 | ERBB2 (0.39) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL21886730 | 0.82 | CHEK1 (0.38) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL30513784 | 0.82 | CHEK1 (0.38) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL28559957 | 0.82 | CHEK1 (0.38) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL21886635 | 0.80 | EGFR (0.35) | EGFRERBB2CHEK1 | |
| SCHEMBL30988767 | 0.75 | GPR119 (0.37) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255772-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-112654612-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2021-04-13 | — | — | CN | disclosed |