SCHEMBL28564337

SCHEMBL28564337

O=C([O-])c1ncc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1.O=C([O-])c1ncc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1.O=C([O-])c1ncc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1.[Ir+3]

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36
PTPN1 P18031 1/20 0.36
HNF4A P41235 1/20 0.35
USP7 Q93009 2/20 0.35
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
KDM4E B2RXH2 3/20 0.34
LMNA P02545 2/20 0.34
LDHA P00338 1/20 0.34
GABRA1 P14867 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA3 P34903 1/20 0.34
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL29074101 0.72 GABRA1 (0.42) ADORA2AADORA1USP7LMNAGABRA1
SCHEMBL8095477 0.71 MAPK1 (0.41) ADORA2AADORA1USP7KDM4ELMNA
SCHEMBL1821593 0.70 ADORA1 (0.44) ADORA2AADORA1USP7MEN1NPC1
Nitric Acid SCHEMBL28587550 0.70 TAAR1 (0.44) ADORA2AADORA1MEN1RAB9AKMT2A
SCHEMBL27573376 0.70 MAP4K4 (0.43) ADORA2AADORA1PTPN1HNF4AUSP7
SCHEMBL4327679 0.69 NPC1 (0.40) ADORA2AADORA1USP7LMNAMEN1
SCHEMBL8025113 0.68 ALDH1A1 (0.46) LMNAMEN1NPC1RAB9AKMT2A
SCHEMBL10205854 0.67 MEN1 (0.50) ADORA2AADORA1USP7MEN1NPC1
SCHEMBL3799864 0.67 NPC1 (0.39) ADORA2AADORA1USP7KDM4ELMNA
SCHEMBL11233688 0.67 LDHA (0.47) PTPN1HNF4AKDM4ELMNALDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112552173-A Preparation method of fluoro alkenyl ketone compound 山东领海生物科技有限公司 2021-03-26 CN claimed