Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28571792 | 0.79 | LMNA (0.44) | EPHX1MMEPPARGPPARACTSS | |
| SCHEMBL28598197 | 0.76 | CTSS (0.45) | EPHX1MMEPPARGCTSSCTSK | |
| SCHEMBL2720266 | 0.73 | EPHX1 (0.57) | EPHX1MMEMEN1KMT2AACACB | |
| SCHEMBL13643239 | 0.73 | EPHX1 (0.57) | EPHX1MMEMEN1KMT2AACACB | |
| SCHEMBL8310103 | 0.73 | CTSS (0.67) | CTSSCTSK | |
| SCHEMBL2617401 | 0.73 | CTSS (0.67) | CTSSCTSK | |
| SCHEMBL7340685 | 0.72 | CTSS (0.47) | EPHX1MMECTSSCTSKACACB | |
| SCHEMBL10562986 | 0.72 | CTSS (0.47) | EPHX1MMECTSSCTSKACACB | |
| SCHEMBL4072985 | 0.72 | MME (0.43) | EPHX1MMEPPARGPPARACTSS | |
| SCHEMBL7328879 | 0.72 | CA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112661671-B | Preparation method of Sacubitril intermediate | 江苏阿尔法药业股份有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-112661671-A | Preparation method of Sacubitril intermediate | 江苏阿尔法药业有限公司 | 2021-04-16 | — | — | CN | disclosed |