Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1937035 | 0.86 | EPHX2 (0.37) | EPHX1LMNANPC1RAB9A | |
| SCHEMBL1936444 | 0.86 | PPARG (0.41) | EPHX1PPARGPPARA | |
| SCHEMBL28652308 | 0.84 | SRR (0.45) | EPHX1PPARGPPARALMNANPC1 | |
| SCHEMBL1935049 | 0.82 | EPHX2 (0.39) | EPHX1KMT2ALMNA | |
| SCHEMBL28474974 | 0.81 | CA2 (0.47) | — | |
| SCHEMBL28703866 | 0.79 | KMT2A (0.38) | KMT2AHDAC1HDAC6LMNANPC1 | |
| SCHEMBL2512713 | 0.79 | EPHX1 (0.49) | MMEEPHX1MEN1KMT2AACACB | |
| SCHEMBL18039530 | 0.74 | MEN1 (0.41) | MMEEPHX1MEN1KMT2AACACB | |
| SCHEMBL28617150 | 0.74 | GAA (0.46) | MEN1KMT2A | |
| SCHEMBL476130 | 0.74 | PPARD (0.42) | PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |