Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068036 | 1.00 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 | |
| SCHEMBL20061342 | 1.00 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 | |
| SCHEMBL20061343 | 0.78 | METAP2 (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 | |
| SCHEMBL20068033 | 0.74 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28575779 | 0.74 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20061346 | 0.74 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28565071 | 0.72 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 | |
| SCHEMBL20061345 | 0.72 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 | |
| SCHEMBL20081373 | 0.72 | FABP3 (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 | |
| SCHEMBL18332819 | 0.70 | CASP3 (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690433-B | Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating PI3 kinase-associated diseases comprising the same as active ingredient | 韩国化学研究院 | 2021-04-09 | — | — | CN | disclosed |