Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520018 | 0.80 | ALDH1A1 (0.61) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL28375510 | 0.70 | MEN1 (0.61) | LMNAALDH1A1POLBMEN1KMT2A | |
| Fluoride SCHEMBL28908418 | 0.70 | MEN1 (0.61) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL1520522 | 0.70 | ALDH1A1 (0.49) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL30162800 | 0.69 | BACE1 (0.59) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL29976879 | 0.69 | MEN1 (0.64) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL20323150 | 0.69 | ALDH1A1 (0.44) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL28562087 | 0.68 | ALDH1A1 (0.43) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL1520717 | 0.68 | ALDH1A1 (0.43) | LMNAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL29152496 | 0.68 | HDAC4 (0.35) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447483-A | Indole oxide spiro dihydrofuran skeleton and preparation method thereof | 青岛农业大学 | 2024-01-26 | — | — | CN | claimed |
| CN-113200993-A | Synthesis method of oxindole spirodihydrofuran compound | 浙江工业大学 | 2021-08-03 | — | — | CN | claimed |
| CN-117447483-A | Indole oxide spiro dihydrofuran skeleton and preparation method thereof | 青岛农业大学 | 2024-01-26 | — | — | CN | disclosed |
| CN-117447483-A | Indole oxide spiro dihydrofuran skeleton and preparation method thereof | 青岛农业大学 | 2024-01-26 | — | — | CN | disclosed |
| CN-113200993-A | Synthesis method of oxindole spirodihydrofuran compound | 浙江工业大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-113200993-A | Synthesis method of oxindole spirodihydrofuran compound | 浙江工业大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-113200993-A | Synthesis method of oxindole spirodihydrofuran compound | 浙江工业大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-109096298-B | Asymmetric synthesis method of chiral benzofuran spiro-oxoindole compound | 浙江工业大学 | 2021-04-06 | — | — | CN | disclosed |