Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23832817 | 0.77 | PDK2 (0.44) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL28562087 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL1520018 | 0.75 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL1520522 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL18981138 | 0.72 | EGFR (0.57) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL1520717 | 0.70 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL15703418 | 0.69 | POLB (0.40) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL28375510 | 0.69 | MEN1 (0.61) | ALDH1A1KMT2AMEN1POLBGAA | |
| Fluoride SCHEMBL28908418 | 0.69 | MEN1 (0.61) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL28565197 | 0.69 | LMNA (0.46) | ALDH1A1KMT2AMEN1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840540-B2 | Dimers of covalent NFKB inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2023-12-12 | — | — | US | disclosed |
| US-11840540-B2 | Dimers of covalent NFKB inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2023-12-12 | — | — | US | disclosed |
| US-20230174548-A1 | SYMBIOTIC PRODRUGS FOR THE TREATMENT OF CANCER AND OTHER DISEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-08 | — | — | US | disclosed |
| US-20220009941-A1 | Dimers of Covalent NFKB Inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2022-01-13 | — | — | US | disclosed |
| WO-2021188855-A1 | SYMBIOTIC PRODRUGS FOR THE TREATMENT OF CANCER AND OTHER DISEASES | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2021-09-23 | — | — | WO | disclosed |
| US-20190322680-A1 | Dimers of Covalent NFKB Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-10-24 | — | — | US | disclosed |
| WO-2018119177-A1 | DIMERS OF COVALENT NFKB INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2018-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009941-A1 | Dimers of Covalent NFKB Inhibitors | NFKBIA, IKBKB, NFKB2 | ALDH1A1 3908/4885KMT2A 1133/4885MEN1 3932/4885 |
| US-20230174548-A1 | SYMBIOTIC PRODRUGS FOR THE TREATMENT OF CANCER AND OTHER DISEASES | NFKBIA, NFRKB, IKBKB | ALDH1A1 2443/4885KMT2A 2742/4885MEN1 3329/4885 |
| US-11840540-B2 | Dimers of covalent NFKB inhibitors | NFKBIA, IKBKB, NFKB2 | ALDH1A1 3908/4885KMT2A 1133/4885MEN1 3932/4885 |
| US-20190322680-A1 | Dimers of Covalent NFKB Inhibitors | NFKBIA, IKBKB, NFKB2 | ALDH1A1 4048/4885KMT2A 1190/4885MEN1 3911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.