Tetrahydrofuran

Tetrahydrofuran

SCHEMBL28565880

C1CCOC1.CC(=O)OCC(C)(C)C

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.34
LMNA P02545 3/20 0.34
HSD17B10 Q99714 1/20 0.34
TSHR P16473 2/20 0.32
KDM4E B2RXH2 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
POLB P06746 1/20 0.32
USP2 O75604 1/20 0.32
APOBEC3A P31941 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
RECQL P46063 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697625 0.82
SCHEMBL28138895 0.80 ALDH1A1 (0.46) ALDH1A1LMNAHSD17B10TSHRSMN1; SMN2
Ethyl Acetate SCHEMBL6544884 0.77 ALDH1A1 (0.64) ALDH1A1LMNAHSD17B10TSHRPOLB
Ethyl Acetate SCHEMBL15194119 0.77 ALDH1A1 (0.64) ALDH1A1LMNAHSD17B10TSHRPOLB
Ethyl Acetate SCHEMBL130336 0.77 ALDH1A1 (0.64) ALDH1A1LMNAHSD17B10TSHRPOLB
Ethyl Acetate SCHEMBL3776197 0.77 ALDH1A1 (0.64) ALDH1A1LMNAHSD17B10TSHRPOLB
Ethyl Acetate SCHEMBL16332300 0.77 ALDH1A1 (0.64) ALDH1A1LMNAHSD17B10TSHRPOLB
Ethylene Glycol SCHEMBL28229019 0.76 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10TSHRSMN1; SMN2
Ethyl Acetate SCHEMBL1057423 0.75 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10TSHRPOLB
Ethyl Acetate SCHEMBL1873691 0.75 ALDH1A1 (0.61) ALDH1A1LMNAHSD17B10TSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112851623-B Method for preparing epsilon-caprolactone, 6-hydroxycaproic acid and ester thereof by using tetrahydrofurfuryl acetic acid and ester thereof 中国科学院兰州化学物理研究所 2022-04-08 CN claimed
CN-112851623-A Method for preparing epsilon-caprolactone, 6-hydroxycaproic acid and ester thereof by using tetrahydrofurfuryl acetic acid and ester thereof 中国科学院兰州化学物理研究所 2021-05-28 CN claimed
CN-112851623-B Method for preparing epsilon-caprolactone, 6-hydroxycaproic acid and ester thereof by using tetrahydrofurfuryl acetic acid and ester thereof 中国科学院兰州化学物理研究所 2022-04-08 CN disclosed
CN-112851623-A Method for preparing epsilon-caprolactone, 6-hydroxycaproic acid and ester thereof by using tetrahydrofurfuryl acetic acid and ester thereof 中国科学院兰州化学物理研究所 2021-05-28 CN disclosed