SCHEMBL28565883

SCHEMBL28565883

CCOc1cccc(C)c1-c1cc(C(N)=O)c2c(C(=O)O)ccc(C(=O)O)c2c1C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.40
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C19 P33261 1/20 0.38
MKNK1 Q9BUB5 1/20 0.38
MKNK2 Q9HBH9 1/20 0.38
MYC P01106 1/20 0.37
GLA P06280 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
PDE10A Q9Y233 1/20 0.37
STING1 Q86WV6 1/20 0.37
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
LMNA P02545 2/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
KDM4E B2RXH2 2/20 0.36
HTT P42858 1/20 0.36
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28913018 0.87 CA12 (0.40) HSD17B10MKNK2MYCSTING1KDM4E
SCHEMBL28559363 0.84 MYC (0.40) HSD17B10CYP1A2CYP3A4CYP2C19MYC
SCHEMBL28563448 0.79 MYC (0.36) HSD17B10CYP1A2MYCKDM4E
SCHEMBL28574564 0.76 KDM4E (0.35) TTRCYP1A2MYCL3MBTL1LMNA
SCHEMBL28776459 0.72 CYP1A2 (0.48) HSD17B10CYP1A2CYP3A4MKNK1MKNK2
SCHEMBL28632785 0.72 MYC (0.46) HSD17B10CYP1A2CYP3A4MKNK1MKNK2
SCHEMBL28192819 0.70 LMNA (0.48) CYP1A2CYP3A4CYP2C19GLAL3MBTL1
SCHEMBL8141825 0.69 POLB (0.52) GLAL3MBTL1KDM4EMAPK1RAB9A
SCHEMBL28192820 0.69 MEN1 (0.50) TSHRCYP1A2CYP3A4CYP2C19MKNK1
SCHEMBL28864212 0.69 PLA2G2A (0.53) CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107430359-B Positively-charged single-layer electrophotographic photoreceptor, process cartridge, and image forming apparatus 京瓷办公信息系统株式会社 2021-08-03 CN disclosed
CN-108139698-B Electrophotographic photoreceptor, process cartridge, and image forming apparatus 京瓷办公信息系统株式会社 2021-04-27 CN disclosed