Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550680 | 0.82 | KDM4E (0.47) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL258223 | 0.77 | ALDH1A1 (0.55) | LMNAKDM4EALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL7278161 | 0.75 | KDM4E (0.55) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL352470 | 0.75 | KDM4E (0.53) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL253870 | 0.75 | CYP11B1 (0.52) | NPC1CYP3A4 | |
| SCHEMBL17942663 | 0.75 | DHODH (0.51) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL125290 | 0.74 | LMNA (0.51) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL27836545 | 0.74 | LMNA (0.56) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL252393 | 0.74 | LMNA (0.47) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL253705 | 0.73 | AURKA (0.47) | CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112752762-A | Substituted pyridoindoles for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2021-05-04 | — | — | CN | disclosed |