Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28563885 | 0.91 | STS (0.39) | STSNR1H2NR1H3TACR1KLK7 | |
| SCHEMBL28588244 | 0.86 | PRMT5 (0.37) | STSTACR1KLK7JAK2JAK1 | |
| SCHEMBL24999625 | 0.85 | STS (0.37) | STSNR1H2NR1H3TACR1KLK7 | |
| SCHEMBL28831739 | 0.83 | TACR1 (0.39) | STSTACR1KLK7JAK2JAK1 | |
| SCHEMBL24175977 | 0.83 | TACR1 (0.41) | STSTACR1KLK7JAK2JAK1 | |
| SCHEMBL8107411 | 0.81 | NR1H2 (0.35) | NR1H2NR1H3GPR119 | |
| SCHEMBL27376812 | 0.79 | ABCB1 (0.40) | STSKLK7JAK2JAK1GPR119 | |
| SCHEMBL27223326 | 0.79 | ABCB1 (0.40) | STSKLK7JAK2JAK1GPR119 | |
| SCHEMBL28638548 | 0.79 | STS (0.43) | STSNR1H2NR1H3JAK2JAK1 | |
| SCHEMBL24999952 | 0.78 | TACR1 (0.35) | STSTACR1KLK7L3MBTL1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805389-B | Tricyclic dihydro-imidazo pyrimidinone derivatives, preparation method, pharmaceutical compositions and uses thereof | 上海赛默罗生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-114805389-A | Tricyclic dihydroimidazopyrimidinone derivatives, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-112778331-B | Tricyclic dihydroimidazopyrimidinone derivatives, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-112778331-A | Tricyclic dihydroimidazopyrimidinone derivatives, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2021-05-11 | — | — | CN | disclosed |