Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28567363 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1TSHRPDE4BPDE4D | |
| SCHEMBL28253538 | 0.82 | ROCK1 (0.45) | MAPTALDH1A1TSHRPDE4BSMN1; SMN2 | |
| SCHEMBL28573108 | 0.82 | MAPT (0.40) | MAPTALDH1A1TSHRTHRBSMN1; SMN2 | |
| SCHEMBL28252766 | 0.81 | NR1H4 (0.46) | MAPTALDH1A1TSHRPDE4BSMN1; SMN2 | |
| SCHEMBL28577984 | 0.80 | MEN1 (0.45) | MAPTALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL28566847 | 0.80 | PDE4B (0.45) | ALDH1A1PDE4BSMN1; SMN2RAB9A | |
| SCHEMBL28570315 | 0.80 | MAPT (0.44) | MAPTALDH1A1TSHRGAATHRB | |
| SCHEMBL28567415 | 0.79 | MAPT (0.52) | MAPTALDH1A1TSHRGAATHRB | |
| SCHEMBL28866091 | 0.78 | ALDH1A1 (0.44) | MAPTALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL28564284 | 0.76 | MAPT (0.52) | MAPTALDH1A1TSHRGAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108794460-B | 1,2, 4-oxadiazole-3, 4-dihydroquinoline compound and preparation method and application thereof | 贵州医科大学 | 2021-05-28 | — | — | CN | disclosed |