Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875267 | 0.93 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPTNOS2POLB | |
| SCHEMBL2854395 | 0.92 | MAPT (0.51) | KDM4EALDH1A1MAPTCCR1POLB | |
| SCHEMBL2850026 | 0.92 | KDM4E (0.52) | KDM4EALDH1A1MAPTCCR1POLB | |
| SCHEMBL5927559 | 0.87 | KDM4E (0.51) | KDM4EALDH1A1MAPTNOS2POLB | |
| SCHEMBL5926448 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1MAPTCCR1POLB | |
| SCHEMBL2860267 | 0.85 | ALDH1A1 (0.57) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2855130 | 0.85 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2855120 | 0.84 | MAPT (0.51) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2854519 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1MAPTCCR1POLB | |
| SCHEMBL6699959 | 0.83 | CTSS (0.56) | KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |