Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7197255 | 0.84 | LMNA (0.56) | LMNAHTTALOX15MAPK1NPC1 | |
| SCHEMBL29516583 | 0.75 | LMNA (0.48) | LMNAHTTALOX15MAPK1NPC1 | |
| SCHEMBL24501024 | 0.74 | LMNA (0.50) | LMNAHTTALOX15MAPK1ALDH1A1 | |
| SCHEMBL28214061 | 0.73 | LMNA (0.42) | LMNAHTTALOX15MAPK1NPC1 | |
| SCHEMBL500715 | 0.72 | LMNA (0.56) | LMNAHTTALOX15MAPK1NPC1 | |
| SCHEMBL27990057 | 0.72 | ADORA2A (0.68) | XDHADORA2AADORA1CLK4CSNK1A1 | |
| SCHEMBL17287226 | 0.72 | ALDH1A1 (0.54) | LMNAHTTMAPK1NPC1RAB9A | |
| Formamide SCHEMBL28090638 | 0.71 | ADORA2A (0.47) | LMNAHTTALOX15MAPK1NPC1 | |
| SCHEMBL22360955 | 0.70 | LMNA (0.54) | LMNAHTTALOX15MAPK1NPC1 | |
| SCHEMBL31637095 | 0.70 | LMNA (0.46) | LMNAHTTALOX15MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812074-B | Tetrazine compound and preparation method and application thereof | 四川大学华西医院 | 2022-06-14 | — | — | CN | disclosed |
| CN-112812074-A | Tetrazine compound and preparation method and application thereof | 四川大学华西医院 | 2021-05-18 | — | — | CN | disclosed |