SCHEMBL7197255

SCHEMBL7197255

c1ccc(-c2nnnnc2-c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.56
HTT P42858 2/20 0.56
ADORA2A P29274 1/20 0.52
ADORA1 P30542 1/20 0.52
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
MAPK1 P28482 2/20 0.50
ALOX15 P16050 1/20 0.50
ALDH1A1 P00352 4/20 0.47
SMN1; SMN2 Q16637 5/20 0.46
KDM4E B2RXH2 2/20 0.46
GAA P10253 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
MAPT P10636 2/20 0.45
CSNK1A1 P48729 1/20 0.44
CLK4 Q9HAZ1 1/20 0.44
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
GLA P06280 1/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formamide SCHEMBL28090638 0.85 ADORA2A (0.47) LMNAHTTADORA2AADORA1NPC1
SCHEMBL28568917 0.84 LMNA (0.48) LMNAHTTADORA2AADORA1NPC1
SCHEMBL29516583 0.84 LMNA (0.48) LMNAHTTADORA2AADORA1NPC1
SCHEMBL500715 0.80 LMNA (0.56) LMNAHTTADORA2AADORA1NPC1
SCHEMBL28212978 0.78 LMNA (0.54) LMNAHTTADORA2AADORA1NPC1
SCHEMBL22360955 0.78 LMNA (0.54) LMNAHTTADORA2AADORA1NPC1
SCHEMBL26645766 0.77 LMNA (0.49) LMNAHTTADORA2AADORA1ALOX15
Water SCHEMBL28964119 0.76 LMNA (0.52) LMNAHTTADORA2AADORA1NPC1
Water SCHEMBL28150223 0.76 LMNA (0.52) LMNAHTTADORA2AADORA1NPC1
SCHEMBL65673 0.73 KMT2A (0.59) LMNAHTTADORA2AADORA1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090429-A1 ENGINEERED SPLIT LUCIFERASES MONOD BIO, INC. (US) 2026-04-30 WO claimed
US-20260077068-A1 ATP-INDEPENDENT BIOLUMINESCENT REPORTER VARIANTS TO IMPROVE IN VIVO IMAGING UNIV VIRGINIA PATENT FOUNDATION (US) 2026-03-19 US claimed
US-20250075190-A1 DE NOVO DESIGNED LUCIFERASE UNIVERSITY OF WASHINGTON 2025-03-06 US claimed
EP-4466280-A2 DE NOVO DESIGNED LUCIFERASE University of Washington (US) 2024-11-27 EP claimed
US-20240016933-A1 Methods of Anchoring or Reconstituting Active Molecules on Metabolically Labeled Cells MASSACHUSETTS GEN HOSPITAL (US) 2024-01-18 US claimed
US-20240002908-A1 METHODS OF DETERMINING SURFACE GLYCAN DENSITY MASSACHUSETTS GEN HOSPITAL (US) 2024-01-04 US claimed
US-20230406839-A1 Bifunctional Compounds And Methods Of Using The Same THE GENERAL HOSPITAL CORPORATION 2023-12-21 US claimed
EP-4240421-A1 BIFUNCTIONAL COMPOUNDS AND METHODS OF USING THE SAME The General Hospital Corporation (US) 2023-09-13 EP claimed
WO-2023137417-A2 DE NOVO DESIGNED LUCIFERASE UNIVERSITY OF WASHINGTON (US) 2023-07-20 WO claimed
WO-2022099040-A1 METHODS OF ANCHORING OR RECONSTITUTING ACTIVE MOLECULES ON METABOLICALLY LABELED CELLS THE GENERAL HOSPITAL CORPORATION (US) 2022-05-12 WO claimed
WO-2022099058-A1 METHODS OF DETERMINING SURFACE GLYCAN DENSITY THE GENERAL HOSPITAL CORPORATION (US) 2022-05-12 WO claimed
WO-2022099043-A1 BIFUNCTIONAL COMPOUNDS AND METHODS OF USING THE SAME THE GENERAL HOSPITAL CORPORATION (US) 2022-05-12 WO claimed
US-10202584-B2 Red-shifted luciferase-luciferin pairs for enhanced bioluminescence THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-02-12 US claimed
US-20180057801-A1 RED-SHIFTED LUCIFERASE-LUCIFERIN PAIRS FOR ENHANCED BIOLUMINESCENCE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-03-01 US claimed
WO-2026090429-A1 ENGINEERED SPLIT LUCIFERASES MONOD BIO, INC. (US) 2026-04-30 WO disclosed
US-12595504-B2 Methods for screening compounds for bactericidal activity and for determining the sensitivity of bacterial samples CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2026-04-07 US disclosed
US-20260092308-A1 ANALYTE DETECTION AND QUANTIFICATION EARLY IS GOOD INC (US) 2026-04-02 US disclosed
US-6359091-B1 AS DIELECTRICS IN SEMICONDUCTORS THE DOW CHEMICAL COMPANY 2002-03-19 US disclosed
WO-2001038417-A1 POLYARYLENE COMPOSITIONS WITH ENHANCED MODULUS PROFILES DOW GLOBAL TECHNOLOGIES INC. (US) 2001-05-31 WO disclosed
US-3951941-A POLYAZODYE SAKAI CHEMICAL INDUSTRY COMPANY, LIMITED (JA) 1976-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092308-A1 ANALYTE DETECTION AND QUANTIFICATION EPCAM, MUC1, KLK3 LMNA 1245/4885HTT 3150/4885ADORA2A 652/4885
US-20260077068-A1 ATP-INDEPENDENT BIOLUMINESCENT REPORTER VARIANTS TO IMPROVE IN VIVO IMAGING KCNN2, KCNN1, ATP1B2 LMNA 2914/4885HTT 1720/4885ADORA2A 725/4885
US-20240016933-A1 Methods of Anchoring or Reconstituting Active Molecules on Metabolically Labeled Cells CD4, CD14, CD69 LMNA 3479/4885HTT 4481/4885ADORA2A 2378/4885
US-12595504-B2 Methods for screening compounds for bactericidal activity and for determining the sensitivity of bacterial samples MRPL21, PGLS, CLPP LMNA 1978/4885HTT 3880/4885ADORA2A 3553/4885
US-20180057801-A1 RED-SHIFTED LUCIFERASE-LUCIFERIN PAIRS FOR ENHANCED BIOLUMINESCENCE LUC7L2, SCLY, GLB1 LMNA 1249/4885HTT 3573/4885ADORA2A 2930/4885
US-10202584-B2 Red-shifted luciferase-luciferin pairs for enhanced bioluminescence LUC7L2, SCLY, GLB1 LMNA 1249/4885HTT 3573/4885ADORA2A 2930/4885
US-20230406839-A1 Bifunctional Compounds And Methods Of Using The Same PAICS, PAPSS1, GNE LMNA 4029/4885HTT 3350/4885ADORA2A 913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.