Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.39 |
| ▸ | AXL | P30530 | 5/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21785519 | 0.84 | MET (0.40) | METAXLGSK3AGSK3BALDH1A1 | |
| SCHEMBL24878816 | 0.82 | MET (0.39) | METAXLGSK3AGSK3BALDH1A1 | |
| SCHEMBL21785556 | 0.80 | ALDH1A1 (0.39) | METAXLGSK3AGSK3BALDH1A1 | |
| SCHEMBL14969120 | 0.79 | MET (0.48) | METAXLALDH1A1POLBTYRO3 | |
| SCHEMBL29814284 | 0.78 | MET (0.47) | METAXLALDH1A1POLBTYRO3 | |
| SCHEMBL23071277 | 0.74 | POLB (0.41) | METAXLPOLBTYRO3MERTK | |
| SCHEMBL14969155 | 0.73 | NPC1 (0.51) | METAXLALDH1A1POLBTYRO3 | |
| SCHEMBL18186597 | 0.72 | POLB (0.44) | METAXLPOLBTYRO3MERTK | |
| SCHEMBL21785516 | 0.69 | AXL (0.38) | METAXLALDH1A1TSHRHSD17B10 | |
| SCHEMBL24878818 | 0.69 | POLB (0.36) | METAXLGSK3AGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112930215-A | Pyrazolo [3, 4-b ] pyridine compounds as TAM and MET kinase inhibitors | 阿雷生物药品公司 | 2021-06-08 | — | — | CN | disclosed |