Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 8/20 | 0.39 |
| ▸ | AXL | P30530 | 5/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969120 | 0.79 | MET (0.48) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL21785519 | 0.75 | MET (0.40) | POLBMETAXL | |
| SCHEMBL29814284 | 0.75 | MET (0.47) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL24878816 | 0.74 | MET (0.39) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL28569207 | 0.74 | MET (0.39) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL18186597 | 0.74 | POLB (0.44) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL14969155 | 0.73 | NPC1 (0.51) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL23071306 | 0.73 | ALDH1A1 (0.40) | POLBRXRARXRBRXRGPTGDR2 | |
| SCHEMBL21785556 | 0.72 | ALDH1A1 (0.39) | POLBMETAXLTYRO3MERTK | |
| SCHEMBL23071006 | 0.69 | PLA2G4A (0.46) | POLBRXRARXRBRXRGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |