Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21808141 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL21820524 | 0.85 | NPC1 (0.45) | ALDH1A1KDM4EGAAHSD17B10SMARCA2 | |
| SCHEMBL21820522 | 0.85 | NPC1 (0.45) | ALDH1A1KDM4EGAAHSD17B10SMARCA2 | |
| SCHEMBL21808171 | 0.82 | KDM4E (0.55) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL28573261 | 0.81 | ALDH1A1 (0.64) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL28573263 | 0.81 | ALDH1A1 (0.64) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL28562860 | 0.77 | KMT2A (0.37) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL28569424 | 0.72 | GFER (0.43) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL21808119 | 0.72 | GFER (0.43) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL1663436 | 0.69 | USP2 (0.55) | ALDH1A1KDM4EGAAHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448908-A | Compounds for the treatment of specific leukemias | 拓臻股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115215838-A | Compounds for the treatment of specific leukemias | 拓臻股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-112770745-B | Compounds for the treatment of specific leukemias | 拓臻股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-112770745-A | Compounds for the treatment of specific leukemias | 拓臻股份有限公司 | 2021-05-07 | — | — | CN | disclosed |