Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825342 | 0.83 | ALDH1A1 (0.66) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL29953636 | 0.83 | ALDH1A1 (0.66) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL29263864 | 0.81 | HPGD (0.44) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL4442714 | 0.78 | CA2 (0.49) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL29656806 | 0.78 | HPGD (0.42) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL31409749 | 0.78 | CYP3A4 (0.47) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL25425235 | 0.76 | ALDH1A1 (0.40) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL29470912 | 0.73 | TSHR (0.42) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL28379385 | 0.73 | CYP3A4 (0.42) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL25427280 | 0.71 | CA2 (0.38) | HPGDALDH1A1HTTSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247743-A2 | MODIFIED LEPTIN POLYPEPTIDES AND THEIR USES | AMBRX, INC. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009100255-A2 | MODIFIED LEPTIN POLYPEPTIDES AND THEIR USES | AMBRX, INC. (US) | 2009-08-13 | — | — | WO | disclosed |