SCHEMBL28573129

SCHEMBL28573129

N#Cc1ccc(-c2ccccc2)cc1-n1c2ccccc2c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.43
ATM Q13315 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
ALDH1A1 P00352 7/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HPGD P15428 1/20 0.40
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
IMPDH2 P12268 1/20 0.39
MAOA P21397 3/20 0.39
MAOB P27338 2/20 0.39
MCL1 Q07820 1/20 0.39
HTT P42858 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21116546 0.96 TSPO (0.40) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL21116457 0.96 ALDH1A1 (0.40) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL19062273 0.95 KDM4E (0.42) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL24927125 0.94 CYP11B1 (0.39) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL24926847 0.94 CYP11B1 (0.39) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL19697202 0.93 KDM4E (0.41) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL25904415 0.92 L3MBTL1 (0.47) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL24927044 0.92 CYP11B1 (0.40) KDM4EATML3MBTL1CYP11B1CYP11B2
SCHEMBL21116458 0.91 ALDH1A1 (0.43) KDM4ECYP11B1CYP11B2ALDH1A1LMNA
SCHEMBL21116902 0.91 CYP11B1 (0.42) KDM4ECYP11B1CYP11B2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638874-A Benzonitrile derivative, light-emitting material, and light-emitting element using the same 国立大学法人九州大学 2021-04-09 CN disclosed