SCHEMBL28574091

SCHEMBL28574091

C#Cc1ccc([Si](c2ccc(C#C)cc2)(c2ccc(C#C)cc2)c2ccc(C#C)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.50
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
KEAP1 Q14145 1/20 0.39
PTPN1 P18031 1/20 0.39
EGLN2 Q96KS0 1/20 0.32
GABRA1 P14867 2/20 0.31
GABRG2 P18507 2/20 0.31
GABRB3 P28472 2/20 0.31
GABRA5 P31644 2/20 0.31
GABRA3 P34903 2/20 0.31
GABRA2 P47869 2/20 0.31
CYP1A1 P04798 1/20 0.31
CYP1B1 Q16678 1/20 0.31
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8645965 0.90 HDAC8 (0.42) HDAC8CA12CA1CA2CA4
SCHEMBL5929955 0.90 HDAC8 (0.42) HDAC8CA12CA1CA2CA4
SCHEMBL28871 0.80 HDAC8 (0.59) HDAC8CA12CA1CA2CA4
SCHEMBL24354789 0.78 HDAC8 (0.46) HDAC8CA12CA1CA2CA4
SCHEMBL1099488 0.78 HDAC8 (0.46) HDAC8CA12CA1CA2CA4
SCHEMBL16167842 0.78 HDAC8 (0.46) HDAC8CA12CA1CA2CA4
Ammonia Solution, Strong SCHEMBL22721248 0.77 HDAC8 (0.56) HDAC8CA12CA1CA2CA4
SCHEMBL10481152 0.77 HDAC8 (0.56) HDAC8CA12CA1CA2CA4
SCHEMBL15473033 0.74 HDAC8 (0.42) HDAC8CA12CA1CA2CA4
SCHEMBL6322050 0.72 HDAC8 (0.41) HDAC8CA12CA1CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115572373-A Organic porous polymer for organic dye adsorption and preparation method thereof 山东大学 2023-01-06 CN claimed
CN-112724373-B Functional organic porous polymer and preparation method and application thereof 山东大学 2021-09-21 CN claimed
CN-112724373-A Functional organic porous polymer and preparation method and application thereof 山东大学 2021-04-30 CN claimed
CN-115572373-A Organic porous polymer for organic dye adsorption and preparation method thereof 山东大学 2023-01-06 CN disclosed
CN-112724373-B Functional organic porous polymer and preparation method and application thereof 山东大学 2021-09-21 CN disclosed
CN-112724373-A Functional organic porous polymer and preparation method and application thereof 山东大学 2021-04-30 CN disclosed