Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16167842 | 0.84 | HDAC8 (0.46) | HDAC8KEAP1CA12CA1CA2 | |
| SCHEMBL15473033 | 0.80 | HDAC8 (0.42) | HDAC8KEAP1CA12CA1CA2 | |
| SCHEMBL6226134 | 0.78 | NR1H2 (0.39) | NR1H2NR1H3 | |
| SCHEMBL6434068 | 0.77 | HDAC8 (0.39) | HDAC8KEAP1CA12CA1CA2 | |
| SCHEMBL586534 | 0.76 | NR1H2 (0.50) | NR1H2NR1H3 | |
| SCHEMBL28871 | 0.76 | HDAC8 (0.59) | HDAC8KEAP1CA12CA1CA2 | |
| SCHEMBL9403781 | 0.75 | HDAC8 (0.38) | HDAC8KEAP1CA12CA1CA2 | |
| SCHEMBL24354789 | 0.74 | HDAC8 (0.46) | HDAC8KEAP1CA12CA1CA2 | |
| SCHEMBL1161032 | 0.74 | CYP2A6 (0.52) | HDAC8CA12CA1CA2CA9 | |
| SCHEMBL7630021 | 0.74 | NR1H2 (0.37) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354511-B | Synthesis method of gem-1, 3-eneyne compound | 湖南第一师范学院 | 2022-03-25 | — | — | CN | claimed |
| CN-113354511-A | Synthesis method of gem-1, 3-eneyne compound | 湖南第一师范学院 | 2021-09-07 | — | — | CN | claimed |
| JP-6175083-A | — | — | None | — | — | JP | disclosed |
| CN-118108628-A | Benzocycloheptatriene compound and synthesis method thereof | 华南理工大学 | 2024-05-31 | — | — | CN | disclosed |
| EP-3625218-B1 | PROCESS FOR HYDROCYANATION OF TERMINAL ALKYNES | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2023-03-01 | — | — | EP | disclosed |
| US-20220298185-A1 | Nucleoside Prodrugs and Uses Related Thereto | UNIV EMORY (US) | 2022-09-22 | — | — | US | disclosed |
| CN-109776253-B | Method for selectively synthesizing cis-olefin and trans-olefin by catalyzing semi-reduction of alkyne through palladium hydrogen donor by alcohol | 南通大学 | 2022-07-15 | — | — | CN | disclosed |
| CN-113354511-B | Synthesis method of gem-1, 3-eneyne compound | 湖南第一师范学院 | 2022-03-25 | — | — | CN | disclosed |
| US-11174389-B2 | Phosphole compound | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2021-11-16 | — | — | US | disclosed |
| CN-113354511-A | Synthesis method of gem-1, 3-eneyne compound | 湖南第一师范学院 | 2021-09-07 | — | — | CN | disclosed |
| US-10947186-B2 | Process for hydrocyanation of terminal alkynes | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2021-03-16 | — | — | US | disclosed |
| WO-2008076045-A1 | NOVEL 2-AMINO- 5-ARYL-IMIDAZOL-4 -ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007041166-A2 | HIGHLY OXYGEN PERMEABLE RIGID CONTACT LENSES FROM POLYACETYLENES | THE LAGADO CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070078245-A1 | Highly Oxygen Permeable Rigid Contact Lenses from Polyacetylenes | THE LAGADO CORPORATION (US) | 2007-04-05 | — | — | US | disclosed |
| CN-1184200-C | Bi-aromatic compounds bond by a heteroethynytene radical and pharmaceutical and comsmetic compositions containing same | GALDERMA RES & DEV I (FR) | 2005-01-12 | — | — | CN | disclosed |
| US-6359098-B1 | SHELF LIFE AS ONE-COMPONENT ADDITION-CURABLE ORGANOPOLYSILOXANES, AND EXTENDED POT LIFE FOR TWO-COMPONENT ADDITION-CURABLE ORGANOPOLYSILOXANES, WITHOUT COMPROMISING CROSSLINKING RATES OR LEVELS | WACKER-CHEMIE GMBH (DE) | 2002-03-19 | — | — | US | disclosed |
| EP-1077226-B1 | Curable Polysiloxane Compositions | WACKER CHEMIE GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| EP-1077226-A1 | Curable Polysiloxane Compositions | Wacker-Chemie GmbH (DE) | 2001-02-21 | — | — | EP | disclosed |
| CN-1236359-A | Bi-aromatic compounds bond by a heteroethynytene radical and pharmaceutical and comsmetic compositions containing same | GALDERMA RES & DEV (FR) | 1999-11-24 | — | — | CN | disclosed |
| JP-H06175083-A | OPHTHALMIC LENS MATERIAL | MENICON CO LTD | 1994-06-24 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298185-A1 | Nucleoside Prodrugs and Uses Related Thereto | PNPO, GSTO1, CYP2C18 | HDAC8 1237/4885KEAP1 2277/4885CA12 4339/4885 |
| US-11174389-B2 | Phosphole compound | AR, PHOSPHO1, NR2E3 | HDAC8 3302/4885KEAP1 2967/4885CA12 3802/4885 |
| US-10947186-B2 | Process for hydrocyanation of terminal alkynes | ALKBH3, ALKBH2, ALKBH5 | HDAC8 3610/4885KEAP1 2620/4885CA12 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.