SCHEMBL28575684

SCHEMBL28575684

[CH2]Cc1ccc(C#C[Si](C(C)C)(C(C)C)C(C)C)cc1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 4/20 0.36
ACACB O00763 2/20 0.30
CACNA2D1 P54289 1/20 0.30
CACNB2 Q08289 1/20 0.30
CACNA1C Q13936 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28025725 0.81 ALK (0.36) ALKACACBCACNA2D1CACNB2CACNA1C
SCHEMBL20446355 0.81 LOXL2 (0.44) ALK
SCHEMBL27669074 0.79 CALM1 (0.41) ACACBCACNA2D1CACNB2CACNA1C
SCHEMBL16070697 0.79 ACACB (0.49) ALKACACB
SCHEMBL16070681 0.78 ACACB (0.37) ALKACACB
SCHEMBL28247328 0.76 GRM5 (0.45) ACACBCACNA2D1CACNB2CACNA1C
SCHEMBL30283119 0.76 FFAR1 (0.57) ALK
SCHEMBL16070579 0.75 FFAR1 (0.35) ALKACACBCACNA2D1CACNB2CACNA1C
SCHEMBL1457390 0.75 APP (0.33) CACNA2D1CACNB2CACNA1C
SCHEMBL2609821 0.75 ACACB (0.38) ACACBCACNA2D1CACNB2CACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112812133-B Alpha, alpha-difluoroallyl organometallic compound and preparation method and application thereof 南京工业大学 2022-03-11 CN claimed
CN-112812133-A Alpha, alpha-difluoroallyl organometallic compound and preparation method and application thereof 南京工业大学 2021-05-18 CN claimed
CN-112812133-B Alpha, alpha-difluoroallyl organometallic compound and preparation method and application thereof 南京工业大学 2022-03-11 CN disclosed
CN-112812133-A Alpha, alpha-difluoroallyl organometallic compound and preparation method and application thereof 南京工业大学 2021-05-18 CN disclosed