Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28873044 | 0.85 | GAA (0.39) | TSHRLMNAUSP2ALDH1A1CYP1A2 | |
| SCHEMBL25857189 | 0.84 | DPP4 (0.38) | TSHRDPP4CYP3A4EPHX2HSD17B10 | |
| SCHEMBL21752029 | 0.79 | TSHR (0.47) | TSHRLMNAUSP2ALDH1A1CYP1A2 | |
| SCHEMBL23513339 | 0.79 | DPP4 (0.35) | TSHRDPP4CYP3A4EPHX2HSD17B10 | |
| SCHEMBL17125039 | 0.78 | TSHR (0.36) | TSHRDPP4CYP3A4EPHX2HSD17B10 | |
| SCHEMBL15620816 | 0.78 | TSHR (0.36) | TSHRDPP4CYP3A4EPHX2HSD17B10 | |
| SCHEMBL28815502 | 0.78 | ALDH1A1 (0.38) | TSHRLMNAUSP2ALDH1A1CYP1A2 | |
| SCHEMBL23513275 | 0.77 | DPP4 (0.34) | TSHRDPP4CYP3A4EPHX2HSD17B10 | |
| Bromide SCHEMBL28562616 | 0.76 | DPP4 (0.33) | TSHRDPP4CYP3A4EPHX2HSD17B10 | |
| SCHEMBL4159695 | 0.73 | CYP3A4 (0.40) | TSHRALDH1A1CYP3A4EPHX2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12264135-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | PHARMACOSMOS HOLDING A/S (DK) | 2025-04-01 | — | — | US | disclosed |
| US-20240199556-A1 | Synthesis of 1,4-Diazaspiro[5.5]Undecan-3-One | G1 THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | US | disclosed |
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | G1 THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| CN-112839657-A | Improved synthesis of 1, 4-diazaspiro [5.5] undecan-3-ones | G1治疗公司 | 2021-05-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12264135-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | NDC1, SDC1, SDC2 | TSHR 3147/4885LMNA 419/4885USP2 1000/4885 |
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | NDC1, SDC1, SDC2 | TSHR 3147/4885LMNA 419/4885USP2 1000/4885 |
| US-20240199556-A1 | Synthesis of 1,4-Diazaspiro[5.5]Undecan-3-One | NDC1, SDC1, SDC2 | TSHR 3147/4885LMNA 419/4885USP2 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.