Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21921077 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL5759512 | 0.80 | ALDH1A1 (0.40) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL28905642 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL16979813 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL19785099 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL25881898 | 0.78 | ALDH1A1 (0.39) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL19785451 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL22440558 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1LMNATDP1METAP2 | |
| SCHEMBL30147779 | 0.77 | AXL (0.36) | KDM4EALDH1A1LMNATDP1AXL | |
| SCHEMBL18940676 | 0.77 | AXL (0.36) | KDM4EALDH1A1LMNATDP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112135825-A | Plasma kallikrein inhibitors and uses thereof | 夏尔人类遗传性治疗公司 | 2020-12-25 | — | — | CN | disclosed |