Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 7/20 | 0.45 |
| ▸ | CA2 | P00918 | 7/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4085154 | 0.96 | MGLL (0.48) | MGLLTDP1POLBBRD4CA1 | |
| SCHEMBL30905400 | 0.86 | POLB (0.67) | MGLLTDP1POLBBRD4CA1 | |
| SCHEMBL10322699 | 0.86 | L3MBTL1 (0.53) | TDP1CYP3A4CA1CA2CA12 | |
| SCHEMBL16409222 | 0.84 | TDP1 (0.48) | TDP1BRD4CYP3A4CA1CA2 | |
| SCHEMBL2333929 | 0.84 | CYP4A11 (0.58) | MGLLTDP1POLBBRD4CA1 | |
| SCHEMBL15856116 | 0.83 | CA12 (0.66) | MGLLTDP1POLBCA1CA2 | |
| SCHEMBL24350075 | 0.82 | NPC1 (0.54) | TDP1POLBCA1CA2CA12 | |
| SCHEMBL1760150 | 0.82 | HDAC1 (0.49) | TDP1CA1CA2CA12CA9 | |
| SCHEMBL21221559 | 0.82 | CYP4A11 (0.57) | MGLLTDP1POLBBRD4CA1 | |
| SCHEMBL1929771 | 0.82 | SIGMAR1 (0.52) | TDP1CYP3A4CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072521-B | ROR gamma t inhibitor and application thereof in medicines | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-113072542-B | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-113072521-A | ROR gamma t inhibitor and application thereof in medicine | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-113072542-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |