SCHEMBL28584159

SCHEMBL28584159

CC(C)(C)c1cnc(Cl)c(F)c1OC(N)=O

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 6/20 0.32
FEN1 P39748 6/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28584575 0.84 ALOX5AP (0.33) ALOX5APFEN1
SCHEMBL1699173 0.81
SCHEMBL31577428 0.80 ALOX5AP (0.31) ALOX5APFEN1
SCHEMBL31577426 0.80 ALOX5AP (0.33) ALOX5APFEN1
SCHEMBL31577430 0.79 ALOX5AP (0.30) ALOX5APFEN1
SCHEMBL17209603 0.77 SIRT1 (0.32)
SCHEMBL31281920 0.73
SCHEMBL1699385 0.73 SIRT1 (0.31)
SCHEMBL28903820 0.71 CCNC (0.31)
SCHEMBL28549352 0.69 KIF11 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163022-A1 PARP1 INHIBITORS SYNNOVATION THERAPEUTICS, INC. 2025-05-22 US disclosed
CN-113072551-B Nitrogen-containing biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-08-13 CN disclosed
CN-113072551-A Nitrogen-containing biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2021-07-06 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163022-A1 PARP1 INHIBITORS PARP1, PARP11, PARP12 ALOX5AP 2154/4885FEN1 59/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.