Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TACR2 | P21452 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | PNLIP | P16233 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850458 | 0.91 | MAPT (0.56) | MAPTPOLBSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL26673838 | 0.89 | MAPT (0.51) | MAPTPOLBSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL26674014 | 0.85 | KCNK3 (0.60) | MAPTKDM4ELMNASMN1; SMN2RAB9A | |
| SCHEMBL26673937 | 0.85 | KCNK3 (0.60) | MAPTKDM4ELMNASMN1; SMN2RAB9A | |
| SCHEMBL26855509 | 0.81 | MAPT (0.46) | MAPTKDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2855473 | 0.81 | MAPT (0.71) | MAPTPOLBCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2852245 | 0.79 | MAPT (0.53) | MAPTPOLBKDM4ELMNASMN1; SMN2 | |
| SCHEMBL5924285 | 0.78 | GRM5 (0.69) | MAPTPOLBLMNATP53KMT2A | |
| SCHEMBL26673940 | 0.77 | GRM5 (0.61) | MAPTPOLBSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2857557 | 0.77 | BRPF1 (0.51) | MAPTSMN1; SMN2RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |