Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564515 | 0.77 | BLM (0.46) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL371419 | 0.72 | BLM (0.43) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL2148327 | 0.71 | BLM (0.41) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL2148514 | 0.70 | PAOX (0.40) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL2148490 | 0.70 | PAOX (0.40) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL3795216 | 0.69 | BLM (0.50) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL4368473 | 0.69 | BLM (0.48) | BLMDRD3GABBR2GABBR1CYP1A2 | |
| SCHEMBL29183296 | 0.68 | BLM (0.62) | BLMDRD3CYP1A2TSHRTHPO | |
| SCHEMBL12085572 | 0.68 | CA12 (0.43) | CYP1A2TSHRTHPOMEN1KMT2A | |
| SCHEMBL8673115 | 0.67 | BLM (0.47) | BLMDRD3GABBR2GABBR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283682-B | Preparation method of isotope labeled amifostine metabolite | 梯尔希（南京）药物研发有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-115137759-B | Pharmaceutical composition for radiation protection and preparation method and application thereof | 浙江大学 | 2024-04-12 | — | — | CN | disclosed |
| CN-116283682-A | Preparation method of stable isotope labeled amifostine metabolite | 梯尔希（南京）药物研发有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-112745347-B | Preparation method of amifostine trihydrate | 重庆大学附属肿瘤医院 | 2021-11-23 | — | — | CN | disclosed |
| CN-112745347-A | Preparation method of amifostine trihydrate | 青岛联吉生物医疗科技有限公司 | 2021-05-04 | — | — | CN | disclosed |