SCHEMBL28592452

SCHEMBL28592452

C=Cc1ccccc1NC(=O)c1cccc2ccccc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.64
MAPT P10636 2/20 0.57
KDM4E B2RXH2 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
RAB9A P51151 5/20 0.55
NPC1 O15118 4/20 0.55
GAA P10253 1/20 0.54
GFER P55789 1/20 0.53
MMP3 P08254 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
DEGS1 O15121 1/20 0.52
CHRNB2 P17787 1/20 0.52
CHRNB4 P30926 1/20 0.52
CHRNA3 P32297 1/20 0.52
CHRNA4 P43681 1/20 0.52
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 P62805 1/20 0.52
EP300 Q09472 1/20 0.52
PRMT1 Q99873 1/20 0.52
PLK1 P53350 1/20 0.51
MEN1 O00255 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21275460 0.82 RAB9A (0.76) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL26728248 0.82 ALDH1A1 (0.45) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL26728292 0.82 ALDH1A1 (0.45) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL9281809 0.78 GFER (0.76) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL7672569 0.78 H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 (0.69) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL28326260 0.78 ALDH1A1 (0.61) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL21446829 0.77 KDM4E (0.72) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL3182095 0.77 ALDH1A1 (0.67) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL27491350 0.77 CYP1A2 (0.70) ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A
SCHEMBL26459825 0.77 ALDH1A1 (0.46) ALDH1A1MAPTNPC1GAASLC16A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113106473-B Method for preparing 1, 3-benzoxazine derivative through continuous electrochemical microreactor device 南京工业大学 2022-02-18 CN disclosed
CN-113106473-A Method for preparing 1, 3-benzoxazine derivative through continuous electrochemical microreactor device 南京工业大学 2021-07-13 CN disclosed