Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859054 | 0.86 | POLB (0.71) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL15401642 | 0.80 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL2857889 | 0.78 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL28218732 | 0.77 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL7699111 | 0.76 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL2736553 | 0.75 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL13753976 | 0.75 | KDM4E (0.69) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL8508465 | 0.74 | MAPT (0.51) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL28219067 | 0.73 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8507468 | 0.72 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |