Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850762 | 0.87 | POLB (0.47) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL2859256 | 0.78 | NPC1 (0.73) | NPC1RAB9ATAAR1LMNASMN1; SMN2 | |
| SCHEMBL2862872 | 0.74 | CCR1 (0.47) | NPC1RAB9AGAAKMT2A | |
| SCHEMBL7576847 | 0.73 | KMT2A (0.45) | NPC1RAB9ALMNAKMT2AMAPT | |
| SCHEMBL2658763 | 0.73 | ALDH1A1 (0.50) | NPC1RAB9AGAALMNASMN1; SMN2 | |
| SCHEMBL2854621 | 0.72 | TSHR (0.58) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL6277045 | 0.72 | NPC1 (0.62) | NPC1RAB9ATAAR1GAASMN1; SMN2 | |
| SCHEMBL2095490 | 0.71 | TAAR1 (0.69) | NPC1RAB9ATAAR1GAASMN1; SMN2 | |
| SCHEMBL2852350 | 0.71 | NPC1 (0.53) | NPC1RAB9ATAAR1GAAHDAC3 | |
| SCHEMBL158220 | 0.70 | HDAC3 (0.78) | NPC1RAB9ATAAR1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |