Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 9/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609837 | 0.90 | EZH2 (0.48) | EZH2EZH1 | |
| SCHEMBL28597396 | 0.88 | CCR5 (0.48) | EZH2EPHX2PPARGEZH1 | |
| SCHEMBL28605092 | 0.88 | POLB (0.49) | PARP1 | |
| SCHEMBL28596693 | 0.87 | EPHX2 (0.52) | EZH2EPHX2PPARGPPARAMAPK14 | |
| SCHEMBL28602648 | 0.87 | P2RX7 (0.50) | EZH2EPHX2EZH1DAO | |
| SCHEMBL29473814 | 0.85 | EZH2 (0.42) | EZH2EZH1PARP1 | |
| SCHEMBL28918826 | 0.85 | EZH2 (0.42) | EZH2EZH1PARP1 | |
| SCHEMBL28600423 | 0.85 | EZH2 (0.41) | EZH2EPHX2NAMPTEZH1 | |
| SCHEMBL29473802 | 0.85 | EZH2 (0.41) | EZH2EPHX2NAMPTEZH1 | |
| SCHEMBL16935193 | 0.85 | ALDH1A1 (0.47) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045494-B | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2022-04-26 | — | — | CN | disclosed |
| CN-113045494-A | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2021-06-29 | — | — | CN | disclosed |