Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29394293 | 1.00 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL29391420 | 0.79 | PRMT1 (0.45) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21644023 | 0.79 | TDP1 (0.47) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28601628 | 0.79 | PRMT1 (0.45) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2781010 | 0.77 | RAB9A (0.59) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2329401 | 0.77 | RAB9A (0.50) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL30147275 | 0.74 | ALDH3A1 (0.63) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18305644 | 0.74 | ALDH3A1 (0.63) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL11556220 | 0.72 | PRMT1 (0.48) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21672257 | 0.71 | MAPT (0.50) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164476-A | Small molecule inhibitor of DYRK1/CLK and application thereof | 代表亚利桑那大学的亚利桑那校董会 | 2021-07-23 | — | — | CN | disclosed |