Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | TDO2 | P48775 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501311 | 1.00 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL8501511 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL31552887 | 0.84 | KDM4E (0.63) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL13870935 | 0.83 | PDGFRB (0.61) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL13870921 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL3463591 | 0.81 | KDM4E (0.68) | SMN1; SMN2ALDH1A1MAPTHPGDLMNA | |
| SCHEMBL13870922 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL6237278 | 0.81 | RAB9A (0.52) | SMN1; SMN2ALDH1A1MAPTHPGDLMNA | |
| SCHEMBL29351353 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPTGLAGAA | |
| SCHEMBL30228475 | 0.79 | KDM4E (0.66) | SMN1; SMN2ALDH1A1MAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121427-B | Quinoline derivative and preparation method and application thereof | 广东工业大学 | 2022-04-01 | — | — | CN | disclosed |
| CN-113121427-A | Quinoline derivative and preparation method and application thereof | 广东工业大学 | 2021-07-16 | — | — | CN | disclosed |