Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28597754 | 0.79 | PARP1 (0.37) | PARP1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL8249959 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTMEN1RECQL | |
| SCHEMBL20692209 | 0.77 | NLRP3 (0.45) | PARP1ALDH1A1NLRP3CA2 | |
| SCHEMBL18007608 | 0.76 | PARP1 (0.37) | PARP1 | |
| SCHEMBL23862477 | 0.73 | PARP1 (0.47) | PARP1ALDH1A1KDM4EMAPTPTGS1 | |
| SCHEMBL18007632 | 0.73 | NLRP3 (0.47) | ALDH1A1NLRP3CA2USP2 | |
| SCHEMBL18378490 | 0.73 | MAPT (0.34) | PARP1MAPTNLRP3PTGS1PTGS2 | |
| SCHEMBL22010905 | 0.73 | PARP1 (0.33) | PARP1ALDH1A1 | |
| SCHEMBL24295490 | 0.72 | PTGS1 (0.33) | PARP1NLRP3CA2PTGS1PTGS2 | |
| SCHEMBL20692210 | 0.70 | NLRP3 (0.41) | PARP1ALDH1A1NLRP3CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164763-A | NLRP3 inhibitor | 英夫拉索姆有限公司 | 2021-07-23 | — | — | CN | disclosed |