Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28599875 | 0.90 | DHODH (0.35) | DHODHKEAP1NFE2L2KMT2A | |
| SCHEMBL28611549 | 0.81 | KEAP1 (0.35) | DHODHKEAP1NFE2L2 | |
| SCHEMBL30800345 | 0.81 | KEAP1 (0.35) | DHODHKEAP1NFE2L2 | |
| SCHEMBL20560749 | 0.78 | GAA (0.39) | DHODHKEAP1NFE2L2NPC1RAB9A | |
| SCHEMBL29742278 | 0.78 | GAA (0.39) | DHODHKEAP1NFE2L2NPC1RAB9A | |
| SCHEMBL29742271 | 0.78 | GAA (0.39) | DHODHKEAP1NFE2L2NPC1RAB9A | |
| SCHEMBL9686323 | 0.78 | KEAP1 (0.51) | KEAP1NFE2L2NPC1MAPTRAB9A | |
| SCHEMBL25414127 | 0.76 | DHODH (0.34) | DHODH | |
| SCHEMBL31020499 | 0.76 | DHODH (0.33) | DHODHNLRP3PKM | |
| SCHEMBL29962647 | 0.76 | DHODH (0.34) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112920183-A | Compounds as KRAS-G12C inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2021-06-08 | — | — | CN | disclosed |