Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502237 | 0.91 | KEAP1 (0.43) | KEAP1NFE2L2CASP1TSHRMAPT | |
| SCHEMBL860929 | 0.82 | KEAP1 (0.57) | KEAP1NFE2L2CASP1TSHRNPC1 | |
| SCHEMBL6170105 | 0.81 | KEAP1 (0.47) | KEAP1NFE2L2CASP1TSHRMAPT | |
| SCHEMBL9221236 | 0.81 | HPGD (0.48) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9805883 | 0.79 | SMN1; SMN2 (0.41) | TSHRMAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10501891 | 0.79 | KEAP1 (0.66) | KEAP1NFE2L2CASP1ALPL | |
| SCHEMBL8871815 | 0.78 | GPR35 (0.35) | TSHRMAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10616453 | 0.78 | GPR35 (0.35) | TSHRMAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10472145 | 0.78 | WDR5 (0.35) | TSHRMAPTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL28599872 | 0.78 | DHODH (0.37) | KEAP1NFE2L2CASP1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61072753-A | — | — | None | — | — | JP | disclosed |
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0191451-B1 | NOVEL 1,8-NAPHTHYRIDINE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-08-02 | — | — | EP | disclosed |
| US-4738968-A | 1,8-naphthyridine derivatives useful as anti-bacterial agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| EP-0132845-B1 | NOVEL 1,8-NAPHTHYRIDINE DERIVATIVES, AND PROCESS FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1988-04-13 | — | — | EP | disclosed |
| US-4649144-A | Antibacterial 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1987-03-10 | — | — | US | disclosed |
| EP-0191451-A1 | Novel 1,8-naphthyridine derivatives and processes for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1986-08-20 | — | — | EP | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |
| JP-S6172753-A | PYRIDYL KETONE DERIVATIVE | DAINIPPON PHARMACEUT CO LTD | 1986-04-14 | — | — | JP | disclosed |
| EP-0132845-A2 | Novel 1,8-Naphthyridine derivatives, and process for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | disclosed |